IOANNIS K. DIMITRAKOPOULOS
OBSTETRICIAN - GYNAECOLOGIST
Gynaecology - Obstetrics - Investigation and Treatment of Infertility - Assisted reproduction Contributer Obstetrician, “MITerA“, & “LITO“ Hospitals - Contributer in Fertility and Gynaecology Clinics “FUTURE FAMILY“
Private Medical Clinic Dr I. K. Dimitrakopoulos MD Phd Obstetrician - Gynaecologist:
196, Gounari Str., 166 74 Glyfada
Tel. +30 210 6716126 | Mob. +30 6940 296060
Prof. Univ Dr. Teofil Mehedinti, Dr. Dimitrakopoulos K. Ioannis. “Edometriosis and infertility. A cytohistologic and clinical study“ (December 2008).
Fully trained and licensed specialist in Obstetrics and Gynecology at the General Prefectural Hospital of Patra “Agios Andreas“, district of Ahaia Greece (May 2014).
Commence of private medical practice as a Specialist in Obstetrics and Gynecology at his clinic in Glyfada. 196, Gounari Dimitriou Avenue (October 2014).
Assessment of the quality of the oocyte, prediction of IVF treatment outcome and improvement of IVF success rates based upon meta- bolic profile of follicular fluid, blood serum and urine.
Infertility is an extremely prevalent problem, affecting one in every seven couples, and as result in vitro fertilisation (IVF) has become increasingly popular since it was pioneered in 1978.
As understanding of fertility and embryology has developed, the procedures and techniques in assisted conception have been ever improving, and as a result, the number of live births resulting from IVF or ICSI has increased since the early 90s.
Worldwide, the live birth rate per IVF cycle varies from 17.2% to 31%. These success rates are still unsatisfactorily low.
The development of controlled ovarian stimulation in the 1980s enabled the production of multiple mature oocytes and hence mul- tiple embryo transfer, improving the chances of pregnancy in an IVF cycle.
Today, gonadotrophins are routinely administered to women undergoing IVF in an attempt to improve the chances of conception. The drawback to multiple embryo transfer, however, is that the patient has a greater chance of developing a multiple pregnancy, which carries an increased risk of maternal and infant morbidity. Infants from multiple pregnancies are more likely to suffer late midtrimester miscarriage or have a low birth weight and/or be born prematurely and as a result may require intensive neonatal care facilities and are at greater risk of being born with long term disabilities such as cerebral palsy, deafness, and visual impairment requiring long term support services. The most common maternal complications associated with multiple pregnancies include high blood pressure, preeclampsia, increased likelihood of cae- sarean section, venous thromboembolism, postpartum haemorrhage, and gestational diabetes.
While IVF is hampered by poor success rates and the increasing pressure to reduce multiple embryo transfers, a major objective in reproductive medicine currently is to find a method for identifying the best embryos for transfer.
Therefore a great body of research has been undertaken with aims of identifying biomarkers to determine oocyte and embryo quality and predict IVF outcome.
Infertility, subfertility and syndromes or conditions that influence fertility such as Polycystic Ovary Syndrome (PCOS) Pelvic Inflam- matory Disease (PID) or Endometriosis. are manifested by specific changes in metabolic pathways which influence biofluids such as Follicular Fluid (FF) and blood serum and urine.
Metabolomics can be applied to assisted conception by obtaining and examining the metabolic profiles of the above mentioned biofluids providing us the opportunity not only to predict IVF outcome but also to restore the physiologic metabolic pathways, increase fertility, improve the quality of oocytes and embryos and ameliorate IVF success rates.
Metabolomics has numerous applications in female reproduction. These include metabolomics of Follicular Fluid (FF), embryo culture medium, oocytes and their related cells, and the introduction of metabolomics techniques to gynecologists including applications on cervical mucus, uterine matter, the pelvis, ovarian tissue, and FF.
Studies have indicated that metabolic differences between embryos may be indicative of their potential to result in a pregnancy
The following articles can be found on the page Dr. Dimitrakopou- los on the site of Med-Professionals:
THE EFFECT OF OOCYTE QUALITY ON INFERTILITY, EMBRYONIC DEVELOPMENT AND ADULT LIFE Follicular Fluid (FF) composition and fertility Plasma and urine composition and fertility